ESR 12 vision / project
Molecular control of the human blood-CSF barrier in health and neuroinflammation
In this project we aim to identify molecules and pathways involved in human blood-CSF barrier (BCSFB) dysfunction in neuroinflammatory disorders, with a focus on multiple sclerosis, using RNA sequencing. Relevance of identified pathways and altered expression thereof will be investigated using functional assays. Ultimately, we aim to unravel the role of the BCSFB in health and neuroinflammation.
Identification of molecular pathways involved in BCSFB dysfunction will allow us to define novel therapeutic targets for restoring this brain barrier in neuroinflammatory disorders.
Stichting VU University Amsterdam & VU Medical Center Amsterdam, Molecular Cell Biology and Immunology, Netherlands
Elga de Vries
Early Stage Researcher
Sabela Rodríguez Lorenzo